Prof. Maurizio Muscaritoli
Presentation Roadmap/ Summary
- The aim of this presentation is to give a brief overview of omega-3-fatty acids as important regulators of cellular function.
- Omega-3 fatty acids are essential food components mainly derived from marine products such as algae, fish (blue fish in particular) and some crustaceans.
- Besides their role as nutrients, omega-3 fatty acids, and eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid in particular, are involved in the modulation of systemic inflammatory response by either counterbalancing the pro-inflammatory actions of omega-6 fatty acids or by promoting the resolution of inflammation acting as precursors of specialized pro-resolving mediators such as resolvins.
- Omega-3 fatty acids supplementation in cancer patients may contribute to the maintenance of body weight and lean body mass.
At the conclusion of the presentation, the participant will be able to:
- Understand the nutritional and physiological role of omega-3 fatty acids
- Understand the rationale of omega-3 fatty acid supplementation
- Recognize the role of omega-3 fatty acids in cancer nutrition
Key Takeaways/ Fast Facts
- Omega -3 fatty acids belong to a family of molecules with different chemical structure and function
- EPA supplementation in cancer may positively impact on clinical outcome
- Omega-3 fatty acid supplementation in cancer should be an integral part of a multimodal treatment ensuring optimal macronutrient intake and a certain degree of physical activity
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3. Daenen LG, Cirkel GA, Houthuijzen JM, Gerrits J, Oosterom I, et al.: Increased Plasma Levels of Chemoresistance-Inducing Fatty Acid 16:4(n-3) After Consumption of Fish and Fish Oil. JAMA Oncol 1, 350–8, 2015.