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Malnutrition prevalence in cancer populations and impact on clinical outcome – insights from a prospective observational study

Prof Maurizio Muscaritoli

Prof. Maurizio Muscaritoli

Presentation Roadmap/ Summary

  • Cancer has a negative impact on nutritional status and body composition.
  • Progressive weight loss and body mass index reduction are independent predictors of increased mortality.
  • Pathogenesis of cancer-related weight loss and cachexia is multifactorial and may depend on the disease itself and/or the side effects of antineoplastic treatments.
  • The aim of this presentation is to show that cancer patients may be at risk of malnutrition or malnourished even at first medical oncology visit i.e. even before undergoing radio-chemotherapy.

Learning Objectives

At the conclusion of the presentation, the participant will be able to:

  1. Understand the pathophysiology and impact of cancer-related malnutrition
  2. Recognize the components of impaired nutritional status in cancer
  3. Identify those cancer patients in those nutritional surveillance and treatment should be prioritized

Key Takeaways/ Fast Facts

  • Malnutrition has a deleterious impact on cancer patients’ prognosis
  • A significant number of cancer patients is at risk of malnutrition or already malnourished at first medical oncology visit, i. e. even before undergoing radio-chemotherapy
  • Prevalence of malnutrition at first medical oncology visit depends on tumor type   

Key references

  1. Muscaritoli M, Lucia S, Farcomeni A, Lorusso V, Saracino V, Barone C et al. Prevalence of malnutrition in patients at first medical oncology visit: the PreMiO study. Oncotarget. 2017;8:79884-96
  2. Hebuterne X, Lemarie E, Michallet M, de Montreuil CB, Schneider SM, Goldwasser F. Prevalence of malnutrition and current use of nutrition support in patients with cancer. JPEN J Parenter Enteral Nutr. 2014; 38:196-204
  3. Martin L, Senesse P, Gioulbasanis I, Antoun S, Bozzetti F, Deans C et al. Diagnostic criteria for theclassification of cancer-associated weight loss. J Clin Oncol. 2015;33:90-9.


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